Endocrine Abstracts

Introduction: Inferior petrosal sinus sampling (IPSS) is considered to be the gold standard for confirming the source of ACTH secretion in patients with Cushing’s syndrome (CS). Prolactin measurement during IPSS can improve diagnostic accuracy and reduces false negative responses.Patients and methods: 56 patients with ACTH-dependent CS were included (45 F/11 M, mean age 43.6±10.8 years and 90.1% Cushing’s disease) diagnosed since 2000. IPS...

Introduction: It has been described that early post-operative cortisol value <2 μg/dl might predict long-term remission while ACTH value has been less described.Objective: To study early post-operative ACTH and cortisol levels in Cushing’s disease patients as predictor factor of long-term remission.Patients: 61 consecutive patients (12 men/49 women), mean age 42.6 years (17–86 years) undergoing transphenoidal hyp...

The Liège Acromegaly Survey is a cross-sectional study on acromegalic patients, developed as an in-house tool in Liège, then extended to other Europeans participating centers. The database differentiates itself from national and multinational registries by adopting a goal oriented approach and it was conceived following a list of open questions on acromegaly. After an initial test run in Liège, the database installation started on mid-March 2010. Thirteen other ...

Methods: We undertook an assessment of patients which were diagnosed with or had their first symptoms of pituitary tumor before the age of 30 and had tumor diameter more than 1 cm without familial history of pituitary adenomas. In patients that consented to genetic analysis, germline mutations in the AIP gene were sought.Results: The study population consisted of 164 patients (61 prolactinomas, 84 somatotropinomas, 16 non-secreting tumors, two pat...